Continuous infusion mitoxantrone in relapsed acute nonlymphocytic leukemia
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چکیده
منابع مشابه
Diaziquone given as a continuous infusion is an active agent for relapsed adult acute nonlymphocytic leukemia.
Diaziquone given as a bolus has not been effective in patients with relapsed or refractory leukemia. Because of in vitro data suggesting enhancement of diaziquone-induced cytotoxicity for human and murine leukemia cells with increased duration of drug exposure and the relatively short terminal plasma half-life of diaziquone, 49 patients (34 acute nonlymphocytic leukemia [ANLL], six chronic myel...
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CUTE NONLYMPHOCYTIC leukemia (ANLL), if untreated, results in the proliferation of malignant cells that infiltrate and replace normal hematopoietic cells in the bone marrow, and death usually results from infection or hemorrhage with a median survival of less than 2 months.’ The two goals of therapy for ANLL are to achieve hematologic remission by cytoreductive chemotherapy and then, after remi...
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A 55-year-old woman being worked up for possible bladder prolapse was found to have pancytopenia. She had no prior history of malignancies or exposure to chemotherapy or radiation. Her CBC showed WBC 1.0 109/L, neutrophils 0.14 109/L, hemoglobin 99 g/L, MCV 100 fL, and platelet count 61 109/L. A peripheral blood smear confirmed the pancytopenia and bone marrow aspirate revealed numerous medium ...
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Intensive sequential chemotherapy with mitoxantrone, 12 mg/m2/d on days 1 through 3, etoposide, 200 mg/m2/d as a continuous infusion on days 8 through 10, and cytarabine, 500 mg/m2/d as a continuous infusion on days 1 through 3 and 8 through 10 was administered to 72 patients aged less than 60 years with previously treated acute myelogenous leukemia (AML). Forty patients had refractory AML (non...
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ژورنال
عنوان ژورنال: Cancer
سال: 1990
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19900615)65:12<2619::aid-cncr2820651203>3.0.co;2-i